When Coca was first introduced the alkaloid cocaine was isolated, and it was used in medicine for its medicinal effects on depression, alcohol and morphine addiction, fatigue, and as a local anesthetic. The result was addiction and dependency to cocaine and its use in medicine was discontinued.
Valium causes a similar change in the brain's reward-inducing dopamine cells as a dose of alcohol, morphine, amphetamine or cocaine.
Oxycontin withdrawal symptoms typically begin as soon as six hours after the last dose and can last up to one week.
The hydrocodone component in Lortab alone can cause an overdose, and is known to cause respiratory depression and other severe adverse reactions including heart failure, heart attack, pulmonary failure, liver or kidney failure, jaundice, amnesia, seizures, blackouts, and coma.