Barbiturates are prescribed as anticonvulsants, sedatives, and general anesthetics but can also induce euphoria, elation, and uninhibited behavior which make them candidates for abuse. If individuals suddenly cease using the barbiturates, symptoms of withdrawal syndrome appear 12-20 hours after the last dose.
Long term PCP users have reported memory loss, difficulties with speech and thinking, depression, and weight loss.
Magic mushrooms contain around 0.2 to 0.4 percent of the hallucinogen psilocybin, along with a trace amount of psilocin; another hallucinogenic substance.
Much like other opiate drugs such as heroin and morphine, fentanyl works on areas of the brain that control pain, pleasure and emotions.