Using magic mushrooms in combination with cocaine may cause a heart attack or stroke and increased blood pressure.
Inhaling the refrigerant Freon to get high may cause sudden sniffing death syndrome, respiratory obstruction and in rare instances, death.
The same exact dose of Methadone could be ineffective for one person, but could also cause a deadly overdose for someone else who isn't tolerant to that dose.
The THC content of hashish has significantly risen since the 1970s.