PCP's effects can vary from person to person and dose to dose, mainly because of significant variations in amount and composition of active compounds.
Long-term methamphetamine users often lose their ability to relate to others socially.
Long term chronic abuse of alcohol, especially when combined with poor nutrition, can lead to permanent damage to vital organs such as the brain and liver.
Inhalants known to cause severe blood oxygen depletion, which can result in death, are aliphatic nitrites, which are also known as poppers, bold and rush on the street.