Smoking freebase cocaine creates a more powerful effect more rapidly, but it is also more dangerous because the safe dose can easily be exceeded.
LSD was the subject of many scientific studies during the 1950's and early 1960's.
Methadone may increase the user's risk of miscarriage and still births, and users also typically give birth to smaller babies.
Ambien is a benzodiazepine prescribed for insomnia. It can disappear from the blood within 2-3 hours and some people find themselves in Ambien-withdrawal before morning.