Methadone withdrawal is so difficult to endure that users who are dependent and addicted often think that they will be on it for the rest of their lives, or at least for many years.
Using magic mushrooms along with cocaine may cause an increased heart rate which could induce a bad trip.
Low price and easy access are both factors alcohol which strongly correlate with high rates of binge drinking among youth.
The acetaminophen component in Vicodin can on its own put the user at risk of overdose.