When crack is cooked down in order to prepare it for injection, diseases can be spread if the tools used to cook the cocaine are themselves contaminated.
Women and low-body-weight males have a lesser capacity to break alcohol down in the same amount of time as a heavier male or female, resulting in higher blood alcohol concentration.
Xyrem, the only prescription form of GHB, is often diverted and abused much like any other pharmaceutical drugs of abuse.
Opiate addicted individuals who do not receive regular doses of opiates begin going through withdrawal, which is a very painful process.