Methadone detoxification can be a very uncomfortable and difficult experience. Withdrawal Symptoms usually begin between twenty-four and forty-eight hours after the user's last dose of the drug. Typical withdrawal symptoms include: stomach cramps, nausea, sweating, tremors, extreme opiate cravings, sneezing, irritability, fever, anxiety, paranoia, fuzzy-headedness, hallucinations and clinical depression. Additionally, methadone withdrawal symptoms tend to continue much longer than heroin withdrawal symptoms. Depending on the dose of methadone you have been taking the symptoms can last for several weeks to several months. Professionals in the field of methadone detoxification typically advise the gradual decrease of the drug over a period of time instead of completely stopping all at once.