Inhaling hexane to achieve a high, a substance found in nitrous oxide, can cause altered perception and motor coordination, limb spasms, hearing and visions loss and in extreme cases, death from lack of oxygen to the brain.
Some Ecstasy users experience loss of fluid via excessive perspiration which puts the body at risk.
Withdrawal symptoms associated with the use of crystal meth include disorientation, confusion, apathy, irritability, itching, and depression that may be so severe that suicide occurs.
LSD produces unpredictable psychological effects known as "trips" which last about 12 hours.